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Collagen and Extracellular Matrix Remodeling GHK-Cu activates fibroblasts, increasing the synthesis of: Type I and III collagen Elastin Proteoglycans Glycosaminoglycans (including hyaluronic acid) This mechanism helps restore structural integrity, improving firmness, elasticity, and volume over time

Chang and colleagues showed in 2011 that the peptide upregulates growth-hormone receptor expression on tendon fibroblasts and increases their migration and survival in culture, an effect that has been reproduced across several Achilles- and quadriceps-tendon transection models in rats

Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim J, Yustein JT, Lee LA, Dang CV

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Comparison to Growth Hormone Safety Profile AOD-9604s safety advantages become particularly apparent when compared to full-length human growth hormone therapy