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Some users report that the copper component can cause temporary stinging at the injection site

Patients experiencing excessive anxiety or needle phobia that prevents adherence to prescribed therapy should discuss this with their healthcare provider

In this form, it loses effectiveness

It is typically not recommended for patients with hepatic or renal impairment, uncontrolled hypertension, history of pancreatitis, or medullary thyroid cancer risk

N Engl J Med 391:109121 Pratley RE, Tuttle KR, Rossing P (2024) Effects of Semaglutide on Heart Failure Outcomes in Diabetes and Chronic Kidney Disease in the FLOW Trial