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FIGURE 5 2.4.1 Vascular remodeling In DR, the RhoA/ROCK signaling pathway is activated by high glucose, which leads to endothelial dysfunction, breakdown of the blood-retinal barrier (BRB), and capillary leakage
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The GIP receptor component is hypothesised to enhance insulin sensitivity and contribute further to appetite regulation, based on preclinical and early clinical data
Resolves for most users after 2-4 weeks at each dose level
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