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When activated, Nrf2 disassociates from its repressor protein KEAP1 that reacts with oxidative radicals, translocates to the nucleus, binds to antioxidant response element and induces the transcription of defensive genes
Increased -3 polyunsaturated fatty acid/arachidonic acid ratios and upregulation of signaling mediator in individuals with autism spectrum disorders
This can lead to the accumulation of toxins, which may contribute to fatigue, brain fog, and more serious conditions like liver dysfunction
Maiorino M, Conrad M, Ursini F
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