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Patients with pernicious anaemia or complete malabsorption typically require lifelong treatment at standard intervals, while those with partial malabsorption may have variable needs
Occasional reports mention gastrointestinal upset including nausea
Practical risk-reduction steps Start with a good history
Women specific considerations Women generally require lower doses relative to body weight compared to men
Approximately 40-50% of people are deficient in B12, with rates reaching 50% among those with hypothyroidism
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