Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)
GLP-1 for Treating ObesityOrigin, History, and Evolution. JAMA , 332(20), 1697-1698
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The most common side effects of tirzepatide are gastrointestinal: nausea, vomiting, diarrhea, constipation, and decreased appetite
Retatrutide is not affected by food in the same way oral medications are it's a subcutaneous injection, absorbed through the lymphatic system independent of digestion