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This mechanism may also help guide the future development of peptide-based therapeutic injectables for hypertension, cardiovascular risk, endothelial dysfunction, and related cardiometabolic conditions

Diabetes Care, 35 (5), 10951097

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Core Biological Themes Covered GLP-1 physiology hunger, insulin, glucose, fat metabolism Microbiome SCFAs GLP-1 axis why microbial metabolites matter Stress & cortisol loops how stress overrides satiety Metabolic flexibility mitochondria, fat oxidation, insulin sensitivity Circadian timing sleep, appetite rhythms, metabolic control