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Any reputable provider should screen for cobalt allergy before administering a B12 injection

As stated before, histamine is a signaling chemical and therefore needs a way to also turn off when the normal immune reaction is complete

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Water soluble/Dispersible Herbal & Nutraceutical Products Formulation Development Nutraceutical, Supplements, Cosmetics"

(PubMed) Bernhard W, Poets CF, Franz AR