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A recent narrative review found that while it can be effective, results are inconsistent and often require ongoing maintenance (PMC narrative review)

Practical checklist before considering use Dose: No validated human dosing exists

The linker system serves two purposes: it maintains appropriate distance between the fatty acid and the peptide backbone to minimize steric interference with receptor binding, and it provides hydrophilic spacer units that improve aqueous solubility relative to directly lipidated peptides