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Weeks 4-5 (2.4-3.0mg): Reaching the maintenance dose

The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

The standard tirzepatide dosage chart for weight loss starts at 2.5 mg once weekly for 4 weeks, then increases by 2.5 mg increments every 4 weeks as tolerated: 2.5 mg 5 mg 7.5 mg 10 mg 12.5 mg 15 mg (maximum)

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