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The AQP1 protein is expressed on both the basolateral and apical membranes where its locations allow it to reabsorb and efflux water
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In addition, acute oral toxicity experiments in mice showed that compound 8u is non-toxic and can tolerate doses up to 2000 mg/kg (Zhang et al., 2019)
specifically, (AEEA)-(-Glu)-(C20 diacid) (where AEEA is 2-[2-(2-aminoethoxy)ethoxy]acetic acid, commonly used as a spacer group in synthetic peptides)
However, just like any treatment, glutathione has some side effects
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