Doseresponse relationships for percent weight change were modeled using generalized additive models and Bayesian hierarchical spline models
2 Methods An umbrella review is used to synthesize and evaluate evidence from existing systematic reviews and meta-analyses, providing a comprehensive and holistic understanding of an issue and the highest level of evidence ( 2.1 Search strategy References for this review were identified by searching PubMed, Embase, the Cochrane Library, Web of Science, and Scopus for related studies from the inception to September 30, 2025
As research continues to evolve, we may gain better insights into optimal microdosing protocols and their long-term effects
Follow-up studies are ongoing but initial results show positive results for significant weight loss
They looked at the average weight loss participants achieved over one year, which showed a clear winner at each interval of time (weight-loss estimates are for 150-pound person): The majority of patients lost at least 5% of their body weight, but the Mounjaro patients had more success compared to those taking Ozempic