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Have relatively uncomplicated medical histories - Patients who are otherwise healthy aside from obesity or common weight-related conditions such as prediabetes or high blood pressure may be appropriate candidates for telehealth supervision
However, individual reactions to medications can vary, and some people may develop back pain while taking semaglutide
Patients should report new or worsening anxiety, low mood, or suicidal thoughts to their GP immediately whilst taking GLP-1 medications
Abbreviations ACI: Autologous chondrocyte implantation Ad: Adenoviral AAV: Adeno-associated virus AD-MSCs: Adipose-derived mesenchymal stem cells BM-MSCs: Bone marrow-derived MSCs BMP: Bone morphogenic protein CaAb: Cartilage-targeted single-chain human antibody fragment ECM: Extracellular matrix ERK: Extracellular signal-regulated kinase HIF-1: Hypoxia inducible factor-1 IGF: Insulin-like growth factor IGF1R: Insulin-like growth factor 1 receptor IRS: Insulin receptor-substrate IL: Interleukin KGN: Kartogenin MACI: Matrix-induced ACI MAPK: Mitogen-activated protein kinase MMP: Matrix metalloproteinases MSCs: Mesenchymal stem cells mTOR: Mammalian target of rapamycin NF-B: Nuclear factor kappa light chain enhancer of activated B cells NPs: Nanoparticles OA: Osteoarthritis PI3K: Phosphatidylinositol 3-kinase SF: Synovial fluid OPF: Oligo (polyethylene glycol) fumarate TGF-1: Transforming growth factor-1 TNF-: Tumor necrosis factor alpha Xp-HB-IGF-1: Heparin bound to IGF-1 RA: Rheumatoid arthritis FOXO: Forkhead-box class O SA--gal: Senescence-associated -galactosidase References Trippel S, et al
