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Over five million patients are treated with TS inhibitors annually 89,90 , expanding our findings beyond the CRC field to other disease indications that use pemetrexed or methotrexate, such as lung cancer

While GLP-1RAs improve inflammatory tone and metabolic signaling, therapy simultaneously reduces nutrient intake and alters gastrointestinal nutrient delivery [20, 21, 48]

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The experiment was repeated three times