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While ROS play essential signaling roles and help regulate cellular redox status, their over-accumulation disrupts cellular integrity, leading to lipid peroxidation, protein degradation, nucleic acid damage, and ultimately cell death

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The appetite effect is mediated through the same GHS-R1a receptor that ghrelin activates, triggering hypothalamic hunger signaling

This procedure falls totally outside the scope of practice of a therapist

Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy