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22,4042 The efficacy of GLP-1 RAs in depressive symptoms primarily derives from animal studies, making it challenging to draw definitive conclusions
The key molecular links are the signals of insulin, adipokines, and toll-like receptors associated with astrocytes and microglia
Funding NIH R01DK128575
Cycling: 4-week cycles followed by 4-8 week breaks allow assessment of lasting effects and prevent potential receptor adaptations
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