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Tyrosinase undergoes catalytic reactions through three oxidative states: oxidized tyrosinase (oxy), met tyrosinase (met), and deoxy tyrosinase (deoxy) 1,16

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We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]