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Dehydration from GI side effects The most common side effects of Ozempic are gastrointestinal, including: Nausea Vomiting Diarrhea These symptoms can lead to dehydration and electrolyte imbalances, which are well-known causes of fatigue

For semaglutide-related constipation, longer-term use may be appropriate under clinician guidance

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On December 1, 2025, WHO conditionally recommended GLP-1 therapies for long-term obesity treatment in adults, alongside behavioral interventions

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