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Doctors know the full dose works, they know stopping fails, and they reason their way into the unmapped territory in between using how these drugs behave in the body and a lot of accumulated experience with real patients
This discrepancy between the current post-marketing findings and prior clinical trial evidence highlights the significance of ongoing pharmacovigilance and real-world evidence studies in identifying rare but potentially serious adverse effects that may not be captured in pre-approval clinical trials
While clinical trials adhere to standardised titration protocols to evaluate efficacy, clinical practice allows for a slower, individualised approach, particularly for patients experiencing early GI symptoms
But thats a nitpick
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