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Poon HF, Hensley K, Thongboonkerd V, Merchant ML, Lynn BC, Pierce WM, et al

Acta Biochim Biophys Sin (Shanghai)

[1] Those who cannot digest or absorb B12 as a result of inherited genetics or damage to the stomach and small intestine require more than can be absorbed from sublingual supplementation

Both methods work, but injections provide stronger benefits, while topical use only targets skin and hair

On the basis of such standard assays, different isoforms are hereinafter referred to as enzymatically active or inactive glutaredoxins for the sake of simplicity (without excluding the possibility that inactive isoforms might actually catalyse other reactions with specialized substrates in vivo )