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Wright, John W, and Joseph W Harding
Aziz TA, Hussain SA, Mahwi TO, Ahmed ZA
GHK-Cu and Cellular Senescence: Downstream Oxidative Mechanism In aged fibroblasts identified by high SA--gal activity, GHK-Cu reduces SA--gal+ cells from 48% to 28% (41%), p16INK4a mRNA 2832%, and p21WAF1 2226% with 7-day treatment indicating partial reversal of the senescent phenotype
The US-FDA initially approved the drug in 1942 (7)
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