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If pancreatitis is suspected, discontinue ZEPBOUND and initiate appropriate management
This upregulation exhausts intracellular GSH, leading to ROS buildup and oxidative DNA damage that can ultimately generate TP53 mutations, a process that is halted when CHAC1 is knocked down (Wada et al., 2018)
Zhao YD, Yin L, Archer S, Lu C, Zhao G, Yao Y, et al
Redox Signal 19 , 20242039 (2013)
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