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An empty stomach allows the peptide to pass through the digestive system with less interference, maximizing its availability to the bodys tissues

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doi:10.3390/foods.12112122 Jurgens TM, Whelan AM, Killian L, Doucette S, Kirk S, Foy E

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Cyclization : Forming a circular peptide backbone eliminates exposed termini, reducing exopeptidase degradation