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Cortisol, the stress hormone, may rise during prolonged caloric deficit, promoting water retention and, in some cases, preferential abdominal fat storage

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Oxidative stress has traditionally been considered in negative terms due to its association with macromolecular damage and triggering cell death through the effects of oxidants on signal transduction pathways, including the activation of sphingomyelinase, caspases and cathepsin D [610]

As Americans drop pounds, however, theyre experiencing a particularly noticeable side-effect: a gaunt, saggy appearance

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