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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials
(2013) 8:e57610
During oxidative stress, Nrf2 translocates into the nucleus to regulate the transcription and expression of antioxidant response elements (ARE), activating the intracellular antioxidant enzyme system to eliminate excess ROS and bolster the cells antioxidant capacity (Suzuki and Yamamoto, 2015)
These are investigational peptides studied in preclinical models for tissue repair and resilience
Sterile or normal saline is sometimes used but offers no preservative, shortening usable life
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