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For GPs who have been prescribing semaglutide off-label to treat conditions such as obesity, while the medicines regulator acknowledges that it is a serious chronic disease that is challenging to manage, at this stage it is recommending that alternatives be considered as supply is expected to remain unstable for some time
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Lifestyle factors including sleep deprivation, chronic stress, and sedentary behavior can blunt weight loss even when appetite suppression is working
1 Introduction In normal healthy individuals, ingestion of food stimulates the secretion of glucagon-like peptide-1 (GLP-1) by L cells in the intestine
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