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Results: In wild-type animals, hepatic EFHD1 levels increased during HFD, and male Efhd1 -/- mice gained less weight (10.61.6% less after 28 weeks HFD), despite similar levels of food intake, activity, and insulin resistance
GLP1-RA treatment is associated with large reductions in both visceral and subcutaneous adipose tissue 51
With respect to its role in glucose homeostasis, GLP-1 is secreted by enteroendocrine L-cells of the distal jejunum & ileum in response to nutrient ingestion
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Reductions in this ratio correlate strongly with cardiovascular risk reduction and metabolic improvement
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