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Substantia nigra-striatal neurons have higher energy demands than other cells, making them more susceptible to mitochondrial dysfunction (42)
Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial
However, patients treated with other hepatotoxic drugs, enzyme inducers or with chronic alcoholism could be more susceptible to its toxic effects, requiring a lower dose to produce toxicity
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