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Weight loss exceeding 10% is needed for improvement in cardiometabolic outcomes [43], which is the main motivation older adults cite for losing weight [73]
A central therapeutic action of GLP-1 RAs in NASH is the improvement of insulin sensitivity in both hepatic and adipose tissues
This study suggests that elevated levels of spontaneous 8OHdG formation as observed in the defective spermatozoa are associated with high rates of ROS formation, enhanced rates of DNA damage, and limited chromatin remodelling
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