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Dwyer CJ, Ward NC, Pugliese A, Malek TR (2016) Promoting immune regulation in type 1 diabetes using low-dose interleukin-2
& Meng, H
Tirzepatide was used at 30 nM and the antagonists were used at 1M concentrations
Using insulin secretion as a read-out in primary human islets provides a platform to interrogate this question in a system that is intimately linked to the glycemic benefits of tirzepatide
Although GLP-1 receptor agonists do not completely eliminate dopamine function, these medications appeared to reduce substance-induced dopamine activity without consistently suppressing baseline dopamine signaling
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