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Oral semaglutide carries similar dosing principles to injections but may require higher doses (up to 14 mg daily) because of lower bioavailability compared to weekly injections
Holter, M
10.1038/nature07455 71
The net effect likely depends on individual patient factors and how well the pro-thrombotic risks are managed
It states that people with significant insulin resistance, type 2 diabetes or BMI-related comorbidities may need clinical assessment, and that if lifestyle optimization plateaus or health indicators worsen, prescription or compounded GLP-1 options become clinically relevant
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