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These differences matter clinically: larger average weight loss translates into bigger improvements in blood pressure, glycemic measures, sleep apnea metrics, mobility, and quality of life for many patients

The genes discussed below each control a different checkpoint in that loop

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120 Long-acting GLP-1 RAs remain in the body for an extended period (eg, with a mean residence time [MRT] of 224 hours at a steady state after administering 14 mg of oral semaglutide)

11 Both studies helped to highlight that patients on exenatide maintained motor function, whereas the control group had deteriorating motor function over the course of around 1 year, indicating that exenatide has some benefit in delaying the progression of PD