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2-HG is taken up by CD8+ T cells, where it destabilizes HIF-1 and acts as an inhibitor of LDH, resulting in reduced chemotaxis, cytotoxic activity and production of IFN- (172174)
Importantly, women should be aware that improved fertility due to weight loss may increase the chance of unplanned conception if not using effective contraception
By working closely with your healthcare team and making sustainable lifestyle changes, you can experience significant improvements in weight management, metabolic health, and overall well-being
Konieczna P, Schiavi E, Ziegler M, Groeger D, Healy S, Grant R, OMahony L (2015) Human dendritic cell DC-SIGN and TLR-2 mediate complementary immune regulatory activities in response to Lactobacillus rhamnosus JB-1
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