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JIMD reports 2022

TD: Tardive Dyskinesia for total (+) active metabolites for tetrabenazine & deutetrabenazine Schneider et al (2021) Adapted from Diana (2007), Schneider et al (2021) & Cheung & Parmar (2022) References: Aminoff MJ (2021): Pharmacologic Management of Parkinsonism & Other Movement Disorders Chapter 28

227 This leads to their degradation and nuclear translocation of NF-B dimers (typically p50/RelA), where they regulate gene transcription