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00:22:04 Steve Small: Yeah, those are some really good common reasons
Based on results from the PIONEER project, oral semaglutide has been approved for treatment in patients with type 2 diabetes, where a 14 mg dose can reduce hemoglobin A1c (HbA1c) levels by up to 1.4% and lead to a weight loss of up to 4.4 kg
GLP-1s work best when they produce steady, consistent results
There is no published trial covering the specific combination at this duration, so the timeline draws on per-compound and analog data: Retatrutide TRIUMPH-4 reached 28.7% mean weight loss at 68 weeks at the 12 mg dose
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