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Metabolites were extracted using 800 L of cold methanol/acetonitrile (1:1, v/v), which also served to precipitate proteins
In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)
This activation pathway is believed to influence calcium channel activity, potentially increasing calcium influx into somatotroph cells
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