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After excluding occasionality, we hypothesized that this may be due to the excitability of SNS by GLP-1RA, especially exenatide, in line with the findings of multiple preclinical studies that showed that Exendin may acutely activate SNS, and this effect independent of insulinotropic and hypothalamus-pituitary-adrenal axis activation can be blocked by GLP-1 antagonist
Conclusion Our study offers novel insights into PBH pharmacotherapy, indicating that PBH patients with a history of cholecystectomy require elevated doses of acarbose for symptom control than PBH patients without such surgical history
Markowska AL et al
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