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The greatest absolute risk reduction comes from improving very elevated glycaemic levels, and a more modest reduction results from near normalisation of plasma glucose levels [2, 14]
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Scott, D
In response to a stimulus step, the heightened amplitude of tax6 mutants was reduced to be closer to wt levels, and exact adaptation was observed in a fraction of the tested worms (Fig 4AD)
The clinical trials ran 26 weeks (about 6 months), and thats generally considered the sweet spot for maximum benefit
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