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Dose-response relationships: Preclinical studies employed single-dose or limited-frequency protocols, leaving repeated high-dose exposure effects uncharacterized

Rotate injection sites (abdomen, thighs, upper arms) to prevent local irritation and lipohypertrophy

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Handling: Let frozen vials warm to room temperature before opening so condensation wont form, and keep the deep-blue solution clear of heat and direct light

Ann Hum Genet