Margulies KB, Hernandez AF, Redfield MM et al (2016) Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: a randomized clinical trial
Heres a quick look at the most common side effects for each medication, as reported by at least 5% of people in clinical trials: For some people, these side effects can become disruptive, leading them to seek an alternative medication
weekly injections is mostly absorption: oral formulations have lower bioavailability than injected versions, which the prescribing clinician accounts for when dosing
Cramps can derail physical performance in an instant
Therefore, the design, discovery, and development of short and long-acting peptide-based GLP-1RAs, including small-molecule agonists are desirable for therapeutic applications beyond T2DM