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There are multiple drug names and mechanisms, ongoing debates about who should take the drugs, questions about cost and access, and anxiety about what happens if you stop taking them

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The 7 Stages Conditions Covered by the Safety Gate Pregnancy & breastfeeding (GLP-1 contraindication) End-stage kidney disease / dialysis End-stage liver disease / cirrhosis Eating disorder (current or prior anorexia / bulimia) Suicidal thoughts or prior suicidal attempt Active cancer diagnosis or treatment Organ transplant / anti-rejection medication Severe GI (gastroparesis, IBD) Untreated substance use (opioid, alcohol including binge drinking, dependence) FDA black-box family history (MTC, MEN2) Type 2 diabetes on insulin or A1c above 10% BMI calculation from height + weight Fridays Health presents its clinical screening as a single multi-select screen titled A bit more about your health with explicit language directly above the options: Any choice below disqualifies you from treatment. This transparency is unusual

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J Med Chem 64(15):1118311194 Lau DCW et al (2021) Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

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