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Whereas, the C-terminus undergoes amidation (conversion of the carboxyl group (-COOH) to an amide group (-NH2)
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IL-17A blockade faces redundancy at multiple levels: IL-17F and IL-17A/F heterodimers signal through the same receptor complex (73), and TNF-/IL-1-driven NF-B activation maintains parallel neutrophil recruitment independently of IL-17A ( Translating pathophysiological mechanisms into clinical benefits requires addressing the limitations of current COPD treatments
