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Preparation and route: Injectable versus oral forms differ in bioavailability and stability
Reduced insulin sensitivity, with increases in fasting blood glucose and HbA1c relative to placebo over 12 months in the same controlled trial, a concern for anyone with existing metabolic risk
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Levels may decline with age, stress, and toxin exposure
Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77
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