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In addition to HF-associated factors, HRQoL is also attributable to comorbidities, the major ones being T2D and obesity

Already Novo was under so much pressure to manufacture pens for obesity and type-2 diabetes patients that it had scaled back making insulin pens in South Africa

The Australian Therapeutic Goods Administration (TGA) classifies semaglutide as a Category D medication for pregnancy, meaning theres evidence of human fetal risk but the benefits may still outweigh risks in certain situations (like poorly controlled diabetes)

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Figure 4: Changes in body weight in A) lean mice and B) obese mice and changes in food intake in C) lean mice and D) obese mice, across the three different experimental treatment groups