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For example, GA can trigger mitochondrial apoptotic signals: it upregulates Bax, downregulates Bcl-2, and activates caspase-9 and 3, leading to programmed cell death in various carcinoma cells (148)
It also influences insulin sensitivity and glucose metabolism, which are essential factors in weight management, especially for those with obesity-related health issues like type 2 diabetes
But thats because the smaller molecules of those drugs, placed against the skin, are easily absorbed
Azar noted that bariatric surgery may also be worth considering
Underdosing, which may affect treatment response
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