The most frequently reported adverse events with combination therapy are gastrointestinal symptoms, including nausea, vomiting, and diarrhea, which are primarily attributable to GLP-1 receptor agonists and may occur more often than with SGLT2 inhibitor monotherapy [24, 43]
Seek urgent medical attention (via NHS 111 or 999 in an emergency) if you experience severe or persistent abdominal pain, persistent vomiting, signs of dehydration (such as dizziness, reduced urination, or extreme thirst), or symptoms suggestive of low blood sugar (such as shakiness, sweating, or confusion)
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Lihong Liu, [email protected] These authors contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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