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In fact, the Cu 2+ -histidine interaction (binding) in nature can match the importance of iron (Fe 2+ ) binding with proteins, and the consequent haem interactions that support the very existence of life (Walton et al., 2023)

Results Fragment-based drug design and chemistry Utilizing actives identified in a quantitative high-throughput screen against Schistosoma mansoni TGR 20,35 , 92 commercially available low molecular weight (MW) compounds/fragments were tested by X-ray crystallography 33,34,36

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