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2 Materials and methods 2.1 Animals All procedures were conducted in accordance with the Directive 2010/63/EU of the European Parliament and of the Council on the protection of animals used for scientific purposes (22.09.2010)

Negative Feedback Loops and Somatostatin GH secretion is regulated by a multi-layered negative feedback system that limits both the amplitude and duration of secretagogue-induced GH pulses

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