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Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R
Mean percent body weight change at 80 weeks, by dose: Retatrutide 4 mg : 19.0% (47.2 lbs) Retatrutide 9 mg : 25.9% (64.4 lbs) Retatrutide 12 mg : 28.3% (70.3 lbs) Placebo : 2.2% (5.5 lbs) Responder rates at the 12 mg dose are the more interesting number for clinicians
Patients should be counseled that these medications are not recommended during pregnancy or lactation
The GLP-1s tirzepatide and semaglutide were in shortage from 2022 until October 2024 and until February 2025, respectively
By understanding their individual benefits and potential synergies, individuals can make informed choices that align with their health goals
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