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Statistical analysis was conducted in SPSS using the MannWhitney test (p 66%)
Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al
Protein metabolism The suppression of protein synthesis, mediated by AMPK, is primarily achieved through direct inhibition of mTORC1
Rectal glutathione delivery eliminates digestive tract and liver metabolism losses, providing 40%-50% more bioavailability through rectal vasculature
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